abstract：BACKGROUND:Anticonvulsants have been used to manage psychiatric conditions for over 50 years. It is recognised that some, particularly valproate, carbamazepine and lamotrigine, are human teratogens, while others including topiramate require further investigation. We aimed to appraise the documentation of this risk by p...

journal_title：BMC psychiatry

authors： Langan J,Perry A,Oto M

更新日期：2013-09-25 00:00:00

abstract：BACKGROUND:The Scale to Assess Unawareness in Mental Disorder (SUMD) is widely used in clinical trials and epidemiological studies but more rarely in clinical practice because of its length (74 items). In clinical practice, it is necessary to provide shorter instruments. The aim of this study was to investigate the val...

journal_title：BMC psychiatry

authors： Michel P,Baumstarck K,Auquier P,Amador X,Dumas R,Fernandez J,Lancon C,Boyer L

更新日期：2013-09-22 00:00:00

abstract：BACKGROUND:Hospitalization is a costly and distressing event associated with relapse during schizophrenia treatment. No information is available on the predictors of psychiatric hospitalization during maintenance treatment with olanzapine long-acting injection (olanzapine-LAI) or how the risk of hospitalization differs...

journal_title：BMC psychiatry

authors： Ascher-Svanum H,Novick D,Haro JM,Bertsch J,McDonnell D,Detke H

更新日期：2013-09-16 00:00:00

abstract：BACKGROUND:Among schizophrenia patients relapsed on an oral antipsychotic (AP), this study compared the impact of switching to atypical AP long-acting injectable therapy (LAT) versus continuing oral APs on hospitalization and emergency room (ER) visit recurrence. METHODS:Electronic records from the Premier Hospital Da...

journal_title：BMC psychiatry

authors： Lafeuille MH,Laliberté-Auger F,Lefebvre P,Frois C,Fastenau J,Duh MS

更新日期：2013-09-10 00:00:00

abstract：BACKGROUND:A number of characteristics associated with Autism Spectrum Disorders (ASD) are over-represented among patients with Anorexia Nervosa (AN) as well as among relatives of these patients. Yet the co-occurrence of autistic traits in AN has not been fully explored and no previous study has directly compared self-...

journal_title：BMC psychiatry

authors： Courty A,Maria AS,Lalanne C,Ringuenet D,Vindreau C,Chevallier C,Pouga L,Pinabel F,Philippe A,Adrien JL,Barry C,Berthoz S

更新日期：2013-09-10 00:00:00

abstract：BACKGROUND:This study focuses on people with complex and severe mental health problems who require inpatient rehabilitation. The majority have a diagnosis of schizophrenia whose recovery has been delayed due to non-response to first-line treatments, cognitive impairment, negative symptoms and co-existing problems such ...

journal_title：BMC psychiatry

authors： Killaspy H,Cook S,Mundy T,Craig T,Holloway F,Leavey G,Marston L,McCrone P,Koeser L,Arbuthnott M,Omar RZ,King M

更新日期：2013-08-28 00:00:00

abstract：BACKGROUND:Numerous genome-wide gene expression studies of bipolar disorder (BP) have been carried out. These studies are heterogeneous, underpowered and use overlapping samples. We conducted a systematic review of these studies to synthesize the current findings. METHODS:We identified all genome-wide gene expression ...

journal_title：BMC psychiatry

authors： Seifuddin F,Pirooznia M,Judy JT,Goes FS,Potash JB,Zandi PP

更新日期：2013-08-15 00:00:00

abstract：BACKGROUND:Once considered to be a disorder restricted to childhood, Attention Deficit/Hyperactivity Disorder (ADHD) is now recognised to persist into adult life. However, service provision for adults with ADHD is limited. Additionally, there is little guidance or research on how best to transition young people with AD...

journal_title：BMC psychiatry

authors： Hall CL,Newell K,Taylor J,Sayal K,Swift KD,Hollis C

更新日期：2013-07-10 00:00:00

abstract：BACKGROUND:This randomized controlled trial (RCT) investigated the effectiveness of a combined treatment for co-morbid Posttraumatic Stress Disorder (PTSD) and severe Substance Use Disorder (SUD). METHODS:Structured Writing Therapy for PTSD (SWT), an evidence-based traumafocused intervention, was added on to Treatment...

journal_title：BMC psychiatry

authors： van Dam D,Ehring T,Vedel E,Emmelkamp PM

更新日期：2013-06-19 00:00:00

abstract：BACKGROUND:We compared the time to discontinuation due to lack of tolerability over 24 weeks in patients suffering from schizophrenia treated with pomaglumetad methionil (LY2140023 monohydrate, the prodrug of metabotropic glutamate 2/3 receptor agonist, LY404039) or standard of care (SOC: olanzapine, risperidone, or ar...

journal_title：BMC psychiatry

authors： Adams DH,Kinon BJ,Baygani S,Millen BA,Velona I,Kollack-Walker S,Walling DP

更新日期：2013-05-22 00:00:00

abstract：BACKGROUND:Attention Deficit Hyperactivity Disorder (ADHD) is often comorbid with psychiatric and developmental disorders. This study aimed to investigate the prevalence of obesity and overweight among Chinese children with ADHD, and to explore which subtypes of the disorder may specifically be associated with obesity/...

journal_title：BMC psychiatry

authors： Yang R,Mao S,Zhang S,Li R,Zhao Z

更新日期：2013-05-10 00:00:00

abstract：BACKGROUND:Experienced discrimination refers to an individual's perception that they have been treated unfairly due to an attribute and is an important recent focus within stigma research. A significant proportion of mental health service users report experiencing mental illness-based discrimination in relation to pare...

journal_title：BMC psychiatry

authors： Jeffery D,Clement S,Corker E,Howard LM,Murray J,Thornicroft G

更新日期：2013-04-20 00:00:00

abstract：BACKGROUND:Studies have reported that up to 60% of individuals with schizophrenia are overweight or obese. This study explored the relationship between obesity and cognitive performance in Chinese patients with schizophrenia. METHODS:Outpatients with schizophrenia aged 18-50 years were recruited from 10 study sites ac...

journal_title：BMC psychiatry

authors： Guo X,Zhang Z,Wei Q,Lv H,Wu R,Zhao J

更新日期：2013-04-09 00:00:00

abstract：BACKGROUND:Structural imaging studies demonstrate brain tissue abnormalities in eating disorders, yet a quantitative analysis has not been done. METHODS:In global and regional meta-analyses of 9 voxel-based morphometry (VBM) studies, with a total of 228 eating disorder participants (currently ill with anorexia nervosa...

journal_title：BMC psychiatry

authors： Titova OE,Hjorth OC,Schiöth HB,Brooks SJ

更新日期：2013-04-09 00:00:00

abstract：BACKGROUND:Relative to intentional memory encoding, which quickly declines in Mild Cognitive Impairment (MCI) and Alzheimer's disease (AD), incidental memory for emotional stimuli appears to deteriorate more slowly. We hypothesised that tests of incidental emotional memory may inform on different aspects of cognitive d...

journal_title：BMC psychiatry

authors： Parra MA,Pattan V,Wong D,Beaglehole A,Lonie J,Wan HI,Honey G,Hall J,Whalley HC,Lawrie SM

更新日期：2013-03-06 00:00:00

abstract：BACKGROUND:Measuring satisfaction with treatment has proved useful to ascertain the treatment features that are most important to the patients, and to explain increased treatment compliance. However, there are few studies that relate satisfaction to other clinical or self-perceived health status indicators. Recent stud...

journal_title：BMC psychiatry

authors： López-Torres J,Párraga I,Del Campo JM,Villena A,ADSCAMFYC Group.

更新日期：2013-02-20 00:00:00

abstract：BACKGROUND:The aim of this study was to develop and evaluate psychometric properties of the Clinical Decision Making Style (CDMS) scale which measures general preferences for decision making as well as preferences regarding the provision of information to the patient from the perspectives of people with severe mental i...

journal_title：BMC psychiatry

authors： Puschner B,Neumann P,Jordan H,Slade M,Fiorillo A,Giacco D,Egerházi A,Ivánka T,Bording MK,Sørensen HØ,Bär A,Kawohl W,Loos S,CEDAR study group.

更新日期：2013-02-04 00:00:00

abstract：BACKGROUND:Deficits in the mismatch negativity (MMN) and P3a components are the most reliable and robust findings in schizophrenia. These abnormalities have also been recently documented in individuals clinically at risk for psychosis, indicating that the MMN may be a potential biomarker for psychosis. However, the at ...

journal_title：BMC psychiatry

authors： Murphy JR,Rawdon C,Kelleher I,Twomey D,Markey PS,Cannon M,Roche RA

更新日期：2013-02-02 00:00:00

abstract：BACKGROUND:Achieving culturally fair assessments of cognitive functioning for Aboriginal people is difficult due to a scarcity of appropriately validated tools for use with this group. As a result, some Aboriginal people with cognitive impairments may lack fair and equitable access to services. The objective of this st...

journal_title：BMC psychiatry

authors： Dingwall KM,Pinkerton J,Lindeman MA

更新日期：2013-01-31 00:00:00

abstract：BACKGROUND:Despite the overall high degree of response to pharmacotherapy, consensus is lacking on how to judge clinical response or define optimal treatment/remission when treating adults with attention-deficit/hyperactivity disorder (ADHD). This study examined clinical response and symptomatic remission in analyses o...

journal_title：BMC psychiatry

authors： Mattingly GW,Weisler RH,Young J,Adeyi B,Dirks B,Babcock T,Lasser R,Scheckner B,Goodman DW

更新日期：2013-01-29 00:00:00

abstract：BACKGROUND:The polymorphism rs6313 (T102C) has been associated with suicidal behavior in case-control and meta-analysis studies, but results and conclusions remain controversial. The aim of the present study was to examine the association between T102C with suicidal behavior in a case-control study and, to assess the c...

journal_title：BMC psychiatry

authors： González-Castro TB,Tovilla-Zárate C,Juárez-Rojop I,Pool García S,Velázquez-Sánchez MP,Genis A,Nicolini H,López Narváez L

更新日期：2013-01-12 00:00:00

abstract：BACKGROUND:In spite of the role of some psychosomatic factors as alexithymia, mood intolerance, and somatization in both pathogenesis and maintenance of anorexia nervosa (AN), few studies have investigated the prevalence of psychosomatic syndromes in AN. The aim of this study was to use the Diagnostic Criteria for Psyc...

journal_title：BMC psychiatry

authors： Abbate-Daga G,Delsedime N,Nicotra B,Giovannone C,Marzola E,Amianto F,Fassino S

更新日期：2013-01-09 00:00:00

abstract：BACKGROUND:Studies in developed countries indicate that psychotic-like symptoms are prevalent in the community and are related to trauma exposure and PTSD. No comparable studies have been undertaken in low-income, post-conflict countries. This study aimed to assess the prevalence of psychotic-like symptoms in conflict-...

journal_title：BMC psychiatry

authors： Soosay I,Silove D,Bateman-Steel C,Steel Z,Bebbington P,Jones PB,Chey T,Ivancic L,Marnane C

更新日期：2012-12-18 00:00:00

abstract：BACKGROUND:Although persistent negative symptoms (PNS) are known to contribute significantly to poor functional outcome, they remain poorly understood. We examined the heuristic value of various PNS definitions and their respective prevalence in patients with first episode psychosis (FEP). We also contrasted those defi...

journal_title：BMC psychiatry

authors： Hovington CL,Bodnar M,Joober R,Malla AK,Lepage M

更新日期：2012-12-06 00:00:00

abstract：BACKGROUND:Numerous structurally unrelated drugs, including antipsychotics, can prolong QT interval and trigger the acquired long QT syndrome (aLQTS). All of them are thought to act at the level of KCNH2, a subunit of the potassium channel. Although the QT-prolonging drugs are proscribed in the subjects with aLQTS, the...

journal_title：BMC psychiatry

authors： Lazarczyk MJ,Bhuiyan ZA,Perrin N,Giannakopoulos P

更新日期：2012-12-05 00:00:00

abstract：BACKGROUND:Treatment disengagement and non-completion poses a major problem for the successful treatment of patients with severe mental illness. Motivation for treatment has long been proposed as a major determinant of treatment engagement, but exact mechanisms remain unclear. This current study serves three purposes: ...

journal_title：BMC psychiatry

authors： Jochems EC,Mulder CL,van Dam A,Duivenvoorden HJ,Scheffer SC,van der Spek W,van der Feltz-Cornelis CM

更新日期：2012-11-24 00:00:00

abstract：BACKGROUND:With an ageing population in most Western countries, people are living longer but often with one or more chronic physical health problems. Older people in physically poor health are at greater risk of developing clinical depression. Cognitive Behavioural Therapy (CBT) and Problem Solving Therapy (PST) have b...

journal_title：BMC psychiatry

authors： Sharpe L,Gittins CB,Correia HM,Meade T,Nicholas MK,Raue PJ,McDonald S,Areán PA

更新日期：2012-11-22 00:00:00

abstract：:Dr. Ougrin's evaluation of cognitive therapy versus exposure in anxiety disorders reported a standardised mean difference [SMD] (95% confidence interval [CI]) of 0.52 (0.37, 0.74) for short-term outcomes and 0.46 (0.29, 0.73) for long-term outcomes in social phobia, and 0.88 (0.69, 1.11) for short-term outcomes and 1....

journal_title：BMC psychiatry

authors： Ebrahim S,Bance S

更新日期：2012-11-20 00:00:00

abstract：BACKGROUND:Depression is a highly prevalent and disabling mental disorder with an incidence rate which appears to be increasing in the developed world. This fact seems to be at least partially related to lifestyle factors. Some hygienic-dietary measures have shown their efficacy as a coadjuvant of standard treatment. H...

journal_title：BMC psychiatry

authors： Garcia-Toro M,Roca M,Monzón S,Vives M,Oliván B,Vicens E,Salva J,Gili M

更新日期：2012-11-16 00:00:00

abstract：BACKGROUND:Symptoms such as medically unexplained vaginal discharge (MUVD) are common and bothersome, leading to potentially unnecessary use of resources. METHODS:A community-based individually randomized controlled trial to assess the effectiveness of a relatively simple, culturally appropriate multi-component interv...

journal_title：BMC psychiatry

authors： Kobeissi L,Mahfoud Z,Khoury B,El Kak F,Ghantous Z,Khawaja M,Nakkash R,Ramia S,Zurayk H,Araya R,Peters TJ

更新日期：2012-11-09 00:00:00

abstract：BACKGROUND:Parental history of mood or anxiety disorders is one of the strongest and most consistent risk factors for the development of these disorders in offspring. Gaps remain however in our knowledge of whether maternal or paternal disorders are more strongly associated with offspring disorders, and whether the ass...

journal_title：BMC psychiatry

authors： Low NC,Dugas E,Constantin E,Karp I,Rodriguez D,O'Loughlin J

更新日期：2012-11-05 00:00:00

abstract：BACKGROUND:Cognitive behavioral therapy (CBT) with exposure and response prevention (ERP) is the first-line treatment for patients with obsessive-compulsive disorder (OCD). However, not all of them achieve remission on a longterm basis. Mindfulness-based cognitive therapy (MBCT) represents a new 8-week group therapy pr...

journal_title：BMC psychiatry

authors： Hertenstein E,Rose N,Voderholzer U,Heidenreich T,Nissen C,Thiel N,Herbst N,Külz AK

更新日期：2012-10-31 00:00:00

abstract：BACKGROUND:In clinical practice, sleep disturbance is often regarded as an epiphenomenon of the primary mental disorder. The aim of this study was to test if sleep disturbance, independently of primary mental disorders, is associated with current clinical state and benefit from treatment in a sample representative of p...

journal_title：BMC psychiatry

authors： Kallestad H,Hansen B,Langsrud K,Ruud T,Morken G,Stiles TC,Gråwe RW

更新日期：2012-10-29 00:00:00

abstract：BACKGROUND:There is a significant treatment gap for patients with depression. A third of sufferers never seek help, and the vast majority of those who do only do so after considerable delay. Little is understood regarding poor help-seeking rates amongst people with depression, with existing research mainly focussed on ...

journal_title：BMC psychiatry

authors： Farmer C,Farrand P,O'Mahen H

更新日期：2012-10-02 00:00:00

abstract：BACKGROUND:Schizophrenia and bipolar depression trials suggest that quetiapine may have an antidepressant effect. OBJECTIVES:This meta-analysis aimed to determine the efficacy, acceptability and tolerability of quetiapine treatment for major depressive disorder (MDD). Only the randomized controlled trials (RCTs) compa...

journal_title：BMC psychiatry

authors： Maneeton N,Maneeton B,Srisurapanont M,Martin SD

更新日期：2012-09-27 00:00:00

abstract：BACKGROUND:We compared the attention abilities of a group of first-episode schizophrenia (FES) patients and a group of healthy participants using the Attention Network Test (ANT), a standard procedure that estimates the functional state of three neural networks controlling the efficiency of three different attentional ...

journal_title：BMC psychiatry

authors： Orellana G,Slachevsky A,Peña M

更新日期：2012-09-22 00:00:00

abstract：BACKGROUND:Schizophrenia and bipolar disorder are chronic debilitating disorders that are often treated with second-generation antipsychotic agents, such as aripiprazole, quetiapine, and ziprasidone. While patients who are hospitalized for schizophrenia and bipolar disorder often receive these agents at discharge, comp...

journal_title：BMC psychiatry

authors： Berger A,Edelsberg J,Sanders KN,Alvir JM,Mychaskiw MA,Oster G

更新日期：2012-08-02 00:00:00

abstract：BACKGROUND:Despite the emergence of mental health problems during adolescence and early adulthood, many young people encounter difficulties accessing appropriate services. In response to this gap, the Australian Government recently established new enhanced primary care services (headspace) that target young people with...

journal_title：BMC psychiatry

authors： McCann TV,Lubman DI

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:The rise of the internet and related technologies has significant implications for the treatment of complex health problems, including the combination of depression and alcohol/other drug (AOD) misuse. To date, no research exists to test the real world uptake of internet and computer-delivered treatment prog...

journal_title：BMC psychiatry

authors： Kay-Lambkin FJ,Baker AL,Healey A,Wolfe S,Simpson A,Brooks M,Bowman J,Childs S

更新日期：2012-07-07 00:00:00

abstract：BACKGROUND:This is an update of a previous meta-analysis published in 2005. METHODS:It includes the data published up to march 2010 for a total of 247 papers and 18,300 cases. Cognitive deficits are examined in 5 different domains: Memory functioning (128 studies), Global cognitive functioning (131 studies), Language ...

journal_title：BMC psychiatry

authors： Fioravanti M,Bianchi V,Cinti ME

更新日期：2012-06-20 00:00:00